Silo Pharma Targets Rheumatoid Arthritis with Latest Deal
March 16th, 2021
Psychedelics, Top Story
Every pathological condition contains disease-specific molecular tags on its vasculature, creating a kind of “zip code” that tells where it’s located in the body. There are peptides, or short chains of amino acids, that home specifically to these pathological conditions and can be used as a highly targeted therapeutic for the delivery of an active ingredient.
Silo Pharma Inc. (OTCQB: SILO) has licensed several of these homing peptides from the University of Maryland-Baltimore, where researchers have uncovered peptides targeting both central nervous system disorders—and now—autoimmune disorders.
Let’s take a look at the company’s most recent agreement with the University of Maryland-Baltimore and what it means for Rheumatoid Arthritis and the rest of its clinical pipeline.
Large & Unmet Medical Condition
Rheumatoid arthritis, or RA, is an autoimmune and inflammatory disease where the immune system attacks healthy cells in the body by mistake, causing inflammation. In particular, the condition causes inflammation in hand, wrist and knee joints, causing long-lasting tissue damage, chronic pain, unsteadiness and deformity.
There are no cures for RA but the condition can be effectively treated and managed with medications and self-management strategies. Disease-modifying antirheumatic drugs, or DMARDs, are a first-line treatment while biological response modifiers, or biologicals, are an effective second-line treatment option—but these come at a high cost.
The global market for RA drugs is forecast to reach US$36.11 billion by 2027, according to Reports and Data. RA patients receiving biologicals spend thousands of dollars per month and must deal with adverse side-effects, such as immune system suppression, which can lead to a greater possibility of infections from a wide range of diseases.
Innovative New Approach
Silo Pharma Inc. (OTCQB: SILO) recently announced an exclusive option agreement with the University of Maryland-Baltimore to explore a novel invention generally known as joint-homing peptides for use in the investigation and treatment of arthritogenic processes. By targeting inflamed endothelium, the peptides could greatly enhance RA drug delivery.
“This option gives Silo access to a unique and potentially vital therapeutic that can also act as a drug delivery platform,” said Chairman and CEO Eric Weisblum. “The ability to deliver compounds directly to targeted areas of the body with this technology could be revolutionary by increasing the efficacy of the treatment while reducing the amount of medication needed.”
The company envisions the homing peptides enhancing the therapeutic effect and decreasing the toxicity of both current and future therapies. The peptides also have the potential for the development of fusion imaging molecules and other nanoparticles to better understand arthritic pathogenesis and leverage precision imaging for diagnosis.
Beyond Rheumatoid Arthritis
Silo Pharma believes that the same homing peptides could apply to other autoimmune diseases. As a whole, the global autoimmune diseases therapeutics market is projected to reach nearly $150 billion by 2025, according to Reportlinker, while diagnostic technologies could represent another lucrative corner of the market.
Beyond these homing peptides, Silo Pharma has been focused on merging traditional therapeutics with psychedelic research to help those suffering from depression, post-traumatic stress disorder, Parkinson’s disease and other rare neurological disorders. The company’s work with the University of Baltimore-Maryland is aimed at developing targeted therapeutics.
Prior to the autoimmune option agreement, the company licensed central nervous system peptides from the University of Maryland-Baltimore, which could be essential in helping psilocybin-based therapies target diseased tissue. The company licensed the IP to Alkido Pharma Inc. (NASDAQ: AIKI) earlier this year for the treatment of cancer patients.
Silo Pharma Inc. (OTCQB: SILO) is well-capitalized after raising $4.275 million from accredited and institutional investors earlier this year. The company plans to use that capital to continue building out its therapeutic pipeline that leverages the University of Maryland-Baltimore’s peptides along with psilocybin and other drugs to treat inflammatory diseases.
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